When the device is asleep, it ignores all but the Wake condition.
The Wake condition requires that either the system processor manually drives the SDA pin low for tWLO, or a data byte of 0x00 be transmitted at a clock rate sufficiently slow so that SDA is low for a minimum period of tWLO. When the device is awake, the normal processor I2C hardware and/or software can be used for device communications. This includes the I/O sequences required to put the device back into Low-Power (i.e., Sleep) mode.
In the I2C mode, the device will ignore a wake sequence that is sent when the device is already awake.
When there are multiple devices on the bus and the I2C interface is run at speeds of less than ~300 kHz1, the transmission of certain data patterns will cause the ATECC608A-TNGTLS devices on the bus to wake up. The lower the frequency the higher the probability that the device wakes up. Because subsequent device addresses transmitted along the bus only match the desired devices, the ATECC608A-TNGTLS will not respond but will be awake. It is recommended that after communicating with another device at slow frequencies, a sleep or idle sequence be issued to place the ATECC608A-TNGTLS back into a known state.