Once the hardware is connected and powered, MPLAB X IDE may be set up for use with the MPLAB PICkit 4 In-Circuit Debugger.
On some devices, you must select the communications channel in the Configuration bits, for example, PGC1/EMUC1 and PGD1/EMUD1. Make sure the pins selected here are the same ones physically connected to the device.
Refer to the MPLAB X IDE Help for details on installing the software and setting up the debugger to work with it.