3.3.2 External Supply
PIC18F47K42 Curiosity Nano can be powered by an external voltage instead of the on-board target regulator. When the Voltage Off (VOFF) pin is shorted to ground (GND) the on-board debugger firmware disables the target regulator, and it is safe to apply an external voltage to the VTG pin.
Programming, debugging, and data streaming are still possible with an external power supply: The debugger and signal level shifters will be powered from the USB cable. Both regulators, the debugger, and the level shifters are powered down when the USB cable is removed.