9.4.6.6 Conversion Results Format
The conversion results can be signed (2’s complement) or unsigned depending on the value of the ADC_EMR.SIGNMODE field.
If conversion results are signed and resolution is less than 16 bits, the sign is extended up to the bit 15 (for example, 0xF43 for 12-bit resolution is read as 0xFF43, and 0x467 is read as 0x0467).