3.1.2.4 Signaling
During USB enumeration, the host OS will start both communication and data pipes of the CDC interface. At this point, it is possible to set and read back the baud rate and other UART parameters of the CDC, but data sending and receiving will not be enabled.
When a terminal connects on the host, it must assert the DTR signal. As this is a virtual control signal implemented on the USB interface, it is not physically present on the board. Asserting the DTR signal from the host will indicate to the on-board debugger that a CDC session is active. The debugger will then enable its level shifters (if available), and start the CDC data send and receive mechanisms.
Deasserting the DTR signal will not disable the level shifters but disable the receiver so no further data will be streamed to the host. Data packets that are already queued up for sending to the target will continue to be sent out, but no further data will be accepted.