17.2 Synchronous and Asynchronous Clocks
As the CPU and the peripherals can be in different clock domains, peripheral accesses by the CPU need to be synchronized. In this case the peripheral includes a Synchronization Busy (SYNCBUSY) register that can be used to check if a sync operation is complete.
In the data sheet, references to Synchronous Clocks are referring to the CPU and bus clocks (MCLK), while asynchronous clocks are generated by the Generic Clock Controller (GCLK).