MPLAB ICE 4 In-Circuit Emulator User's Guide

8.2.3 Debugger to Computer Communication Error Actions

If the MPLAB ICE 4 In-Circuit Emulator and MPLAB X IDE are not communicating with each other:

Unplug and then plug in the debugger.
Reconnect to the debugger.
Try the operation again. It is possible the error was a one-time event.
The version of a pack (DPF/TP) installed in MPLAB X IDE may be incorrect for the target device. See MPLAB X IDE documentation for information on how to install updated packs.
There may be an issue with the computer USB port. See section USB Port Communication Error Actions.

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