13.4.6 Power Consumption vs. Speed
When targeting for either a low-power or a fast acting system, some considerations have to be taken into account due to the nature of the asynchronous clocking of the peripherals:
If clocking a peripheral with a very low clock, the active power consumption of the peripheral will be lower. At the same time the synchronization to the synchronous (CPU) clock domain is dependent on the peripheral clock speed, and will take longer with a slower peripheral clock. This will cause worse response times and longer synchronization delays.