13.25.6.3.8 Phase-locked SOFs
To support the Synchronous Endpoints capability, the period of the emitted Start-of-Frame is maintained while the USB connection is not in the active state. This does not apply for the disconnected/connected/reset states. It applies for active/idle/suspend/resume states. The period of Start-of-Frame will be 1ms when the USB connection is in active state and an integer number of milli-seconds across idle/suspend/resume states.
To ensure the Synchronous Endpoints capability, the GCLK_USB clock must be kept running. If the GCLK_USB is interrupted, the period of the emitted Start-of-Frame will be erratic.