11.2.5.2.3 Step 3. Verify Connection Using Local ICE 4
Connect the MPLAB ICE 4 to your computer using USB. Open and use MPLAB X IDE to verify that you can program and run your test application on the target using the emulator and the ICE 4 breakout board.
If this fails, you need to review your breakout board connections.
Note: You will not be able to get the serial output yet.