38.5.6 Conversion Results Format
The conversion results can be signed (2’s complement) or unsigned, depending on the value of ADC_EMR.SIGNMODE.
If conversion results are signed and resolution is less than 16 bits, the sign is extended up to bit 15 (e.g., 0xF43 for 12-bit resolution is read as 0xFF43, and 0x467 is read as 0x0467).